Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP

Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP

The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell–cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of t...

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Bibliographic Details
Main Authors: Gorisse, L. (Author), Li, Z. (Author), Sacks, D.B (Author), Sayedyahossein, S. (Author), Thines, L. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Ca 2+
Calmodulin
Cell proliferation
Cell signaling
Cell-fate
Collagen
In-vitro
Mammals
Musculoskeletal system
Phosphorylation
Signaling
Signalling pathways
Target genes
Tissue cells
Tissue growth
Transcription
Transcriptional co-activators
Tumorigenesis
Tumors
Tumour suppressor
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