Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

Eukaryotic mRNAs possess a poly(A) tail at their 30-end, to which poly(A)-binding protein C1 (PABPC1) binds and recruits other proteins that regulate translation. Enhanced poly(A)dependent translation, which is also PABPC1 dependent, promotes cellular and viral proliferation. PABP-interacting protei...

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Bibliographic Details
Main Authors: Hoshino, S.-I (Author), Hosoda, N. (Author), Imai, S. (Author), Ishii, Y. (Author), Osawa, M. (Author), Sagae, T. (Author), Sawazaki, R. (Author), Shimada, I. (Author), Yokogawa, M. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Binding interface
Binding proteins
Cellulars
D values
Displacers
Dissociation
Dissociation constant
Eukaryotics
Functional mechanisms
Isothermal titration calorimetry
Proteins
RNA
RNA-recognition motifs
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