Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice

Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice

Although capsaicin has been studied extensively as an activator of the transient receptor potential vanilloid cation channel subtype 1 (TRPV1) channels in sensory neurons, little is known about its TRPV1-independent actions in gastrointestinal health and disease. Here, we aimed to investigate the ph...

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Bibliographic Details
Main Authors: Chen, J. (Author), Chen, X.Y (Author), Chu, F. (Author), Dong, H. (Author), Sellers, Z.M (Author), Wan, H. (Author), Xu, F. (Author), Zhang, F. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amiloride
Blockings
Ca 2+
Cation channels
Cells
Independent action
Intestinal epithelial cells
Ion exchange
Mammals
Na absorptions
Neurons
Sensory neurons
Sodium sulfate
Sulfur compounds
Transient receptor potential vanilloid
Ulcerative colitis
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