Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition

Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition

Glycation is a nonenzymatic posttranslational modification (PTM) known to be increased in the brains of hyperglycemic patients. Alpha-synuclein (αSN), a central player in the etiology of Parkinson’s disease, can be glycated at lysine residues, thereby reducing αSN fibril formation in vitro and modul...

Full description

Bibliographic Details
Main Authors: Buell, A.K (Author), Dominguez-Meijide, A. (Author), Farzadfard, A. (Author), König, A. (Author), Nielsen, J. (Author), Otzen, D.E (Author), Outeiro, T.F (Author), Petersen, S.V (Author), Vasili, E. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Fibril formation
Fibrillization
Glycation
Glycosylation
In-vitro
Lysine residues
Methylglyoxal
Non-enzymatic
Post-translational modifications
Proteins
Sugars
Sweet spot
Synuclein
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items