Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition
Glycation is a nonenzymatic posttranslational modification (PTM) known to be increased in the brains of hyperglycemic patients. Alpha-synuclein (αSN), a central player in the etiology of Parkinson’s disease, can be glycated at lysine residues, thereby reducing αSN fibril formation in vitro and modul...
Main Authors: | Buell, A.K (Author), Dominguez-Meijide, A. (Author), Farzadfard, A. (Author), König, A. (Author), Nielsen, J. (Author), Otzen, D.E (Author), Outeiro, T.F (Author), Petersen, S.V (Author), Vasili, E. (Author) |
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Format: | Article |
Language: | English |
Published: |
American Society for Biochemistry and Molecular Biology Inc.
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |
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