The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

Innate immune signaling by Toll-like receptors (TLRs) involves receptor phosphorylation, which helps to shape and drive key inflammatory outputs, yet our understanding of the kinases and mechanisms that mediate TLR phosphorylation is incomplete. Spleen tyrosine kinase (Syk) is a nonreceptor protein...

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Bibliographic Details
Main Authors: Alexandrov, K. (Author), Curson, J.E.B (Author), Kobe, B. (Author), Li, Y. (Author), Liu, L. (Author), Lucas, R.M (Author), Luo, L. (Author), Mobli, M. (Author), Nanson, J.D (Author), Stow, J.L (Author), Sweet, M.J (Author), Tuladhar, N. (Author), Whitfield, J. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Adapter proteins
Amino acids
Chemical activation
Enzymes
Immunoreceptor tyrosine-based activation motifs
Innate immunes
Lipopolysaccharides
Phosphorylation
Protein tyrosine kinase
Scaffolding proteins
Scaffolds (biology)
Spleen tyrosine kinase
Toll-like receptors
Transmembranes
Tyrosine kinase
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