Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling

The constitutive androstane receptor (CAR) is a nuclear receptor that plays a crucial role in regulating xenobiotic metabolism and detoxification, energy homeostasis, and cell proliferation by modulating the transcription of numerous target genes. CAR activation has been established as the mode of a...

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Bibliographic Details
Main Authors: Kwon, S.M (Author), Li, D. (Author), Li, L. (Author), Li, Z. (Author), Negishi, M. (Author), Peng, X. (Author), Raufman, J.-P (Author), Sueyoshi, T. (Author), Wang, H. (Author), Wang, X.W (Author), Zhang, J. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Cancer development
Cell proliferation
Cell signaling
Constitutive androstane receptors
Detoxification
Diagnosis
Energy cells
Energy homeostasis
Hepatocellular carcinoma
Hepatocyte nuclear factors
Hepatoma cells
Liver cancers
Mammals
Nuclear receptors
Transcription
Tumors
Xenobiotic metabolism
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