Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo

Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo

Follistatin (FS)-like 1 (FSTL1) is a member of the FS-SPARC (secreted protein, acidic and rich in cysteine) family of secreted and extracellular matrix proteins. The functions of FSTL1 have been studied in heart and lung injury as well as in wound healing; however, the role of FSTL1 in the kidney is...

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Main Authors: Dai, C. (Author), Feng, B. (Author), Hambrock, H.O (Author), Hartmann, U. (Author), Huang, H. (Author), Huang, Y. (Author), Lan, H.-Y (Author), Li, J. (Author), Liu, Y. (Author), Mak, K.K (Author), Qin, J. (Author), Wang, Y. (Author), Xia, Y. (Author), Xu, C. (Author), Zeng, Y. (Author), Zhang, X. (Author), Zhang, Y. (Author), Zheng, G. (Author), Zheng, Z.-H (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Calcium-binding domain
Catenin signaling
Cell culture
Extracellular
Fibrogenesis
Follistatin-like 1
Frizzled
FSTL1
FZD
kidney fibrosis
Kidney fibrosis
Ligands
Mammals
Mouse kidney
Proteins
Signaling
Wnt
β-catenin
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