c-Src–mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells

c-Src–mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells

Invadopodia on cancer cells play crucial roles in tumor invasion and metastasis by degrading and remodeling the surrounding extracellular matrices and driving cell migration in complex 3D environments. Previous studies have indicated that microtubules (MTs) play a crucial role in elongation of invad...

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Bibliographic Details
Main Authors: Endo, M. (Author), Ikeda, K. (Author), Minami, Y. (Author), Nishita, M. (Author), Okada, Y. (Author), Saji, T. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Cancer cells
cell invasion
Cell invasion
Cells
Chemical activation
Cytology
Diseases
Elongation
Extracellular matrices
invadopodia
Invadopodium
KIF1C
kinesin
Kinesins
microtubule
Microtubules
phosphorylation
Phosphorylation
Src
tumor cell biology
Tumor cell biology
Tumor invasion
Tumor metastasis
Tumors
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