Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis

Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis

Injurious overloading and inflammation perturbate homeostasis of articular cartilage, leading to abnormal tissue-level loading during post-traumatic osteoarthritis. Our objective was to gain time- and cartilage depth-dependent insights into the early-stage disease progression with an in vitro model...

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Bibliographic Details
Main Authors: Eskelinen, A.S.A (Author), Florea, C. (Author), Frank, E.H (Author), Grodzinsky, A.J (Author), Hung, H.-H.K (Author), Julkunen, P. (Author), Korhonen, R.K (Author), Mikkonen, S. (Author), Nieminen, P. (Author), Tanska, P. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2022
Subjects:
Abnormal tissues
Articular cartilage
Articular cartilages
Biochemistry
Biosynthesis
Cartilage
Cyclic loading
Cyclic loads
Fluorescence microscopy
Glycoproteins
Glycosaminoglycans
Homoeostasis
Inflammation
Injury
Interleukin1
Loading regimes
Pathology
Post-traumatic osteoarthritis
Strain rate
Sulfur compounds
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