Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability

Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability

Background & Aims: The expression and role of methyltransferase SET and MYND domain-containing protein 5 (SMYD5) in inflammatory bowel disease (IBD) is completely unknown. Here, we investigated the role and underlying mechanism of epithelial SMYD5 in IBD pathogenesis and progression. Methods: Th...

Full description

Bibliographic Details
Main Authors: Denning, T.L (Author), Gewirtz, A.T (Author), Gheinani, P.T (Author), Guan, X. (Author), Hou, Y. (Author), Jin, C. (Author), Li, C. (Author), Liu, Y. (Author), Naren, A.P (Author), Sharma, S. (Author), Sun, X. (Author), Xie, Z. (Author), Yang, Z. (Author), Yin, J. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
Colitis
IBD
Mitochondrion
PGC-1α
SMYD5
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items