Determination toxic effects of Hystrix Brachyura Bezoar extracts using cancer cell lines and embryo zebrafish (Danio rerio) models and identification of active principles through GC-MS analysis

Determination toxic effects of Hystrix Brachyura Bezoar extracts using cancer cell lines and embryo zebrafish (Danio rerio) models and identification of active principles through GC-MS analysis

Ethnopharmacological relevance: Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment...

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Bibliographic Details
Main Authors: Ahmed, Q.U (Author), Firus Khan, A.Y (Author), Hilles, A. (Author), Jalal, T.K (Author), Khatib, A. (Author), Nippun, T.S (Author), Noor, S.M (Author), Salleh, M.Z (Author), Seeni, A. (Author), Teh, L.K (Author), Wahab, R.A (Author)
Format: Article
Language:English
Published: Elsevier Ireland Ltd, 2020
Subjects:
A-375 cell line
animal
animal cell
animal experiment
animal extract
animal model
animal tissue
Animals
antineoplastic activity
antineoplastic agent
Antineoplastic Agents
Article
bezoar
Bezoars
biological factor
Biological Factors
Brachyura
bradycardia
Cell Line, Tumor
concentration response
controlled study
craniofacial morphology
cytotoxicity
dose response
Dose-Response Relationship, Drug
drug effect
EC50
embryo
embryo development
Embryonic Development
female
Female
fish model
fluorouracil
Gas Chromatography-Mass Spectrometry
hatching
HeLa cell line
HeLa Cells
human
human cell
Humans
Hystrix brachyura
IC50
In vitro anticancer effect
in vitro study
in vivo study
isolation and purification
LC50
male
Male
mass fragmentography
MCF-7 cell line
MCF-7 Cells
myristic acid
nonhuman
notochord
physiology
porcupine
Porcupine bezoar
porcupine bezoar a
porcupine bezoar b
porcupine bezoar c
Porcupines
procedures
soft tissue
somite
teratogenicity
Traditional medicine
tumor cell line
unclassified drug
zebra fish
Zebrafish
Zebrafish toxicity
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