An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting LPL. We also recently showed that the TG-loweri...

Full description

Bibliographic Details
Main Authors:	Austin, A.K (Author), Balasubramaniam, D. (Author), Beyer, T.P (Author), Chen, Y.Q (Author), Davies, J. (Author), Day, J.W (Author), Ehsani, M. (Author), Fitchett, J.R (Author), Glaesner, W. (Author), Heng, A.R (Author), Jones, B.E (Author), Konrad, R.J (Author), Qian, Y.-W (Author), Russell, A.M (Author), Schroeder, O. (Author), Siegel, R.W (Author), Zhen, E.Y (Author)
Format:	Article
Language:	English
Published:	American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:	angiopoietin-like protein (ANGPTL) apolipoprotein (Apo) epitopes hydrogen-deuterium exchange mass spectrometry (HDXMS) leucine zipper lipoprotein lipase (LPL) molecular modeling nano-imaging transmission electron microscopy (TEM) triglycerides (TG)
Online Access:	View Fulltext in Publisher

Internet

View Fulltext in Publisher

An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif

Internet

Similar Items