The potential for isotope dilution-LC-MS/MS to improve laboratory measurement of C-peptide: Reasons and critical determinants

The potential for isotope dilution-LC-MS/MS to improve laboratory measurement of C-peptide: Reasons and critical determinants

Human C-peptide is secreted in equimolar amounts with insulin by pancreatic beta-cells. Measurement of C-peptide plays an important role in the diagnosis and treatment of diabetes where it is used to evaluate the function of islet cells. However, C-peptide measurement results across different labora...

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Bibliographic Details
Main Authors: Deng, Y. (Author), Liu, Q. (Author), Zhang, C. (Author), Zhao, H. (Author), Zhou, W. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
acromegaly
amino acid sequence
antibody affinity
Article
blood glucose monitoring
body mass
C peptide
cost effectiveness analysis
C-peptide
drug blood level
electrochemical analysis
erythrocyte deformability
health care personnel
hemoglobin A1c
high performance liquid chromatography
human
insulin antibody
ion exchange chromatography
isotope
Isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)
limit of detection
liquid chromatography
liquid chromatography-mass spectrometry
mass spectrometry
mathematical phenomena
measurement accuracy
multiple reaction monitoring
point of care testing
polyacrylamide gel electrophoresis
protein synthesis
quality control
Sample preparation
sensitivity and specificity
signal noise ratio
size exclusion chromatography
standardization
Standardization
ultra performance liquid chromatography
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