A high sensitivity LC-MS/MS method for measurement of 3-methoxytyramine in plasma and associations between 3-methoxytyramine, metanephrines, and dopamine

A high sensitivity LC-MS/MS method for measurement of 3-methoxytyramine in plasma and associations between 3-methoxytyramine, metanephrines, and dopamine

Introduction: Diagnosis of pheochromocytoma and paraganglioma (PPGL) is aided by the measurement of metanephrine (MN) and normetanephrine (NMN). Research suggests that 3-methoxytyramine (3MT), a dopamine (DA) metabolite, may serve as a biomarker of metastasis in patients with paraganglioma. Consider...

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Bibliographic Details
Main Authors: Frank, E.L (Author), Kushnir, M.M (Author), Smy, L. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
3 o methyldopamine
3-Methoxytryamine
adult
article
Article
biological marker
dopamine
Dopamine
drug blood level
female
high performance liquid chromatography
human
human experiment
information processing
limit of detection
limit of quantitation
liquid chromatography-mass spectrometry
Liquid-chromatography tandem mass spectrometry
male
measurement accuracy
metadrenalin
metastasis
multiple reaction monitoring
paraganglioma
Paraganglioma
pheochromocytoma
Pheochromocytoma
Plasma
quality control
quantitative analysis
sensitivity analysis
sensitivity and specificity
solid phase microextraction
validation process
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