MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

More than a year after the COVID-19 pandemic was declared, the need still exists for accurate, rapid, inexpensive and non-invasive diagnostic methods that yield high specificity and sensitivity towards the current and newly emerging SARS-CoV-2 strains. Compared to the nasopharyngeal swabs, several s...

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Bibliographic Details
Main Authors: Bharti, P. (Author), Bland, J. (Author), Chivte, P. (Author), Gaillard, E.R (Author), Kadkol, S.S (Author), LaCasse, Z. (Author), Seethi, V.D.R (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
acetone
acetonitrile
adult
area under the curve
Article
Asymptomatic
athlete
biological marker
centrifugation
clinical article
controlled study
coronavirus disease 2019
COVID-19 testing
female
human
immune response
immunoglobulin
immunoglobulin A
immunoglobulin A antibody
immunoglobulin blood level
immunoglobulin G
immunoglobulin M
immunoglobulin M antibody
Immunoglobulins
limit of detection
limit of quantitation
liquid chromatography-mass spectrometry
machine learning
MALDI-ToF
mathematical analysis
matrix assisted laser desorption ionization time of flight mass spectrometry
nasopharyngeal swab
protein fingerprinting
proteome
quality control
real time polymerase chain reaction
real time reverse transcription polymerase chain reaction
receiver operating characteristic
Saliva
saliva analysis
sensitivity and specificity
sinapic acid
trifluoroacetic acid
virus envelope protein
virus load
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