Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry

Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry

Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic diseases. Identification of sn-1 fatty alcohols and sn-2 fatty acids of different Pls species is necessary to determine the roles and mechanisms of action of Pls in different diseases. Previously, full-scan ta...

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Bibliographic Details
Main Authors: Ahsanul Haque, M. (Author), Azad, A.K (Author), Kobayashi, H. (Author), Md. Sheikh, A. (Author), Nagai, A. (Author), Osago, H. (Author), Sakai, H. (Author), Yano, S. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
animal experiment
animal model
animal tissue
Article
clinical research
controlled study
electrospray
ethanolamine
high performance liquid chromatography
human
human tissue
icosapentaenoic acid
Identification
LC-MS/MS
limit of detection
linoleic acid
liquid chromatography
liquid chromatography-mass spectrometry
male
mass spectrometry
metabolic disorder
molecule
mouse
multiple reaction monitoring
multiple sclerosis
nonhuman
palmitic acid
Phospholipids
plasmalogen
Plasmalogens
Quantification
saturated fatty acid
tandem mass spectrometry
Targeted multiplexed SRM/MS‘
thin layer chromatography
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