Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells

Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells

Bcl-2 family proteins are crucial regulators of apoptosis. Both pro- and antiapoptotic members exist, and overexpression of the latter facilitates evasion of apoptosis in many cancer types. Bcl-2 homology domain 3 (BH3) mimetics are small molecule inhibitors of antiapoptotic Bcl-2 family members, an...

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Bibliographic Details
Main Authors: Jamal, R. (Author), Mazlan, M. (Author), Raja Abdul Rahman, R.N.Z (Author), Tan, J.-K (Author), Then, S.-M (Author), Wan Ngah, W.Z (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2016
Subjects:
alpha tocopherol
analogs and derivatives
apoptosis
Apoptosis
Article
Bax protein (53-86)
Bcl-2
BH3 mimetic
BH3 protein
binding assay
caspase 3
caspase 9
cell death
Cell Line, Tumor
cell membrane depolarization
chemistry
chroman derivative
Chromans
controlled study
cytochrome c
cytosol
drug effects
drug inhibition
enzyme release
fluorescent dye
gamma tocotrienol
Gamma-tocotrienol
human
human cell
Humans
hydrophobicity
mitochondrial membrane potential
molecular docking
molecular mimicry
Molecular Mimicry
neuroblastoma
Neuroblastoma
neuroblastoma cell line
oncoprotein
pathology
peptide fragment
Peptide Fragments
plastochromanol 8
protein bcl 2
Proto-Oncogene Proteins
tumor cell line
Vitamin E
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