Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling

Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling

Introduction: Metformin is a first-line drug for treating type 2 diabetes that regulates the differentiation of mesenchymal stem cells. Its effects on human dental pulp cells (DPCs) remain unknown. This study aimed to investigate the effects of metformin on the proliferation and differentiation of D...

Full description

Bibliographic Details
Main Authors: Gao, X. (Author), Lin, Z. (Author), Ma, T. (Author), Qin, W. (Author), Schneider, A. (Author), Song, B. (Author), Weir, M.D (Author), Xu, H.H.K (Author), Zou, J. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2018
Subjects:
adult
Adult
alkaline phosphatase
Alkaline Phosphatase
AMP-Activated Protein Kinases
AMPK
antidiabetic agent
Blotting, Western
cell differentiation
Cell Differentiation
cytology
Dental Pulp
drug effect
human
Humans
hydroxymethylglutaryl coenzyme A reductase kinase
Hypoglycemic Agents
metabolism
metformin
Metformin
odontoblast
Odontoblasts
proliferation
real time polymerase chain reaction
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
reverse transcription polymerase chain reaction
signal transduction
Signal Transduction
tooth pulp
Western blotting
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items