C5L2 Silencing in Human Pulp Fibroblasts Enhances Nerve Outgrowth Under Lipoteichoic Acid Stimulation

C5L2 Silencing in Human Pulp Fibroblasts Enhances Nerve Outgrowth Under Lipoteichoic Acid Stimulation

Introduction: We recently reported that caries-associated C5a receptor (C5aR) expression and activation result in up-regulation of brain-derived neurotropic factor secretion by pulp fibroblasts inducing prominent neurite outgrowth toward the carious site. Our data further showed a negative regulatio...

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Bibliographic Details
Main Authors: About, I. (Author), Chmilewsky, F. (Author), Chung, S.H (Author), Cooper, L.F (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2018
Subjects:
C5a receptor
C5L2
cell culture
Cells, Cultured
chemokine receptor
cytology
Dental Pulp
drug effect
fibroblast
Fibroblasts
gene expression
Gene Expression
gene silencing
Gene Silencing
genetics
GPR77 protein, human
human
Humans
lipopolysaccharide
Lipopolysaccharides
lipoteichoic acid
nerve outgrowth
neurite
Neurites
physiology
pulp fibroblast
Receptors, Chemokine
RNA, Small Interfering
small interfering RNA
teichoic acid
Teichoic Acids
tooth pulp
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