The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma

Purpose: Perineural invasion (PNI) is a hallmark of salivary adenoid cystic carcinoma (SACC) and represents an important risk factor for local recurrence and poor survival. However, the mechanism of PNI has yet to be explored. We sought to examine the CCL5-CCR5 ligand–receptor interaction between ne...

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Bibliographic Details
Main Authors: Gao, T. (Author), Kang, X. (Author), Li, Y. (Author), Ma, C. (Author), Shen, Z. (Author), Sun, M. (Author)
Format: Article
Language:English
Published: W.B. Saunders 2018
Subjects:
adult
Article
cancer staging
cell invasion
cell migration
chemokine receptor CCR5
coculture
controlled study
distant metastasis
female
human
human cell
human tissue
immunohistochemistry
in vitro study
major clinical study
male
pathogenesis
perineural invasion
protein expression
RANTES
risk factor
salivary adenoid cystic carcinoma
signal transduction
spinal ganglion
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