Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids...

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Bibliographic Details
Main Authors: Bi, H. (Author), Chen, P. (Author), Chen, Y. (Author), Gonzalez, F.J (Author), Guan, L. (Author), Huang, M. (Author), Sun, J. (Author), Wang, Y. (Author), Zhang, H. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
A-549 cell line
Anticancer target
Article
biochemical analysis
cardiolipin
carnitine palmitoyltransferase 1C
cell aging
cell protection
cholesterol plus phosphatidylcholine plus phosphatidylethanolamine plus phosphatidylinositol plus phosphatidylserine plus sphingomyelin
diacylglycerol
disorders of mitochondrial functions
down regulation
gene knockdown
genetic transfection
HCT 116 cell line
histology
human
human cell
Lipid accumulation
lipid peroxidation
Lipid peroxidation
lipid storage
lipidome
lipidomics
Lipidomics
lipogenesis
lipotoxicity
liquid chromatography-mass spectrometry
malonaldehyde
MDA-MB-231 cell line
messenger RNA
Mitochondrial dysfunction
mitochondrial enzyme
mitochondrial membrane potential
mRNA expression level
oxidative stress
Oxidative stress
PANC-1 cell line
phosphatidylcholine
phosphatidylethanolamine
phosphatidylglycerol
reactive oxygen metabolite
real time polymerase chain reaction
small interfering RNA
sphingomyelin
triacylglycerol
unclassified drug
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