Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel

Design and preparation of a new multi-targeted drug delivery system using multifunctional nanoparticles for co-delivery of siRNA and paclitaxel

Drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, the present study tried to incorporate siRNA and paclitaxel (PTX) simultaneously into a novel nanocarrier. The selectivity o...

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Bibliographic Details
Main Authors: Amani, A. (Author), Ebrahimi, H.A (Author), Hamidi, A.A (Author), Nasab, S.H (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
antineoplastic activity
Article
BT-474 cell line
cancer combination chemotherapy
cancer gene therapy
cancer tissue
cell viability
chemical structure
comparative study
conjugation
copolymer
cytotoxicity
data analysis software
degradation
drug delivery system
drug selectivity
encapsulation
feco polyethyleneimine nanoparticle
fluorescence microscopy
folic acid
genetic transfection
glucose
hydrodynamics
in vitro study
internalization (cell)
Magnetic nanoparticles
malignant neoplasm
MCF-7 cell line
MTT assay
multifunctional nanoparticle
nanocarrier
nonviral gene delivery system
optical density
paclitaxel
Paclitaxel
particle size
photon correlation spectroscopy
polyethyleneimine
polylactic acid polyethylene glycol
Polymeric drug delivery
proton nuclear magnetic resonance
siRNA
small interfering RNA
static electricity
synthesis
Targeted drug delivery
thermography
thermostability
transmission electron microscopy
unclassified drug
zeta potential
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