Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae

Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae

Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate (LNA) against carbapenemase-producing Klebsiella pneumoniae (KPC-KP). LNA alone exhibi...

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Bibliographic Details
Main Authors: Ajat, M. (Author), Lai, K.-S (Author), Lim, S.-H.E (Author), Yang, S.-K (Author), Yap, W.-S (Author), Yusoff, K. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
anthranilic acid derivative
Article
bacterial membrane
bacterial outer membrane
bacterial protein
bactericidal activity
bactericide
carbapenemase producing Enterobacteriaceae
Comparative proteomic
comparative proteomics
controlled study
cytoplasm protein
down regulation
drug uptake
ethidium bromide
Klebsiella pneumoniae
KPC-KP
Linalyl anthranilate
lipid peroxidation
membrane damage
Membrane damage
membrane permeability
membrane protein
meropenem
minimum inhibitory concentration
nonhuman
nucleic acid
oxidative stress
reactive oxygen metabolite
regulator protein
ROS
surface charge
terpene derivative
transmission electron microscopy
upregulation
zeta potential
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