Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient

Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient

A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine (TEA), 1,1,3,3-tetramethylguanidine (TMG), and diisopropylamine (DIPA) in the synthetic route of an active pharmaceutical ingredient (API). Due to the severe absorption of amines on GC stationary phases,...

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Bibliographic Details
Main Authors: Qiu, H. (Author), Shou, M. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
1,1,3,3 tetramethylguanidine
amine
Amines
analytical parameters
API
Article
boiling point
chemical reaction
chemical structure
diisopropylamine
flame ionization detection
gas chromatography
GC-FID
limit of detection
limit of quantitation
Method development
Method qualification
reproducibility
retention time
retention time (chromatography)
salicylic acid
sensitivity analysis
signal noise ratio
synthesis
triethylamine
unclassified drug
volatile organic compound
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