Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma

Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma

The purpose of this study was to compare pharmacokinetic (PK) parameters obtained using two newly developed assays, HPLC-UV and UPLC-ESI-MS/MS. Selection of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage setti...

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Bibliographic Details
Main Authors: Cho, H.-Y (Author), Jang, J.-H (Author), Jeong, S.-H (Author), Lee, Y.-B (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
acetic acid
acetonitrile
adult
alanine aminotransferase
albumin
alkaline phosphatase
ammonium formate
area under the curve
Article
aspartate aminotransferase
bilirubin
Biochemical parameters
cefaclor
cefprozil
Cefprozil diastereomers
cholesterol
cholesterol blood level
comparative study
Comparison
controlled study
correlation analysis
creatinine
diastereoisomer
drug absorption
drug bioavailability
drug clearance
drug determination
drug stability
electrospray mass spectrometry
elimination rate constant
formic acid
half life time
high performance liquid chromatography
HPLC-UV
human
human experiment
limit of quantitation
male
matrix effect
measurement accuracy
methanol
minimum plasma concentration
normal human
Pharmacokinetic parameter
pharmacokinetic parameters
reproducibility
sensitivity analysis
steady state
time to maximum plasma concentration
ultra performance liquid chromatography
UPLC-ESI-MS/MS
urea nitrogen blood level
water
young adult
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