Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown. A surrogate analyte D4-cystine was employed to generate calibration curves for the determination of levels of D4-cystine and endogenous cysti...

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Bibliographic Details
Main Authors: Aa, J. (Author), Hong, Y. (Author), Jiao, L. (Author), Li, S. (Author), Lu, Z. (Author), Wang, G. (Author), Zhang, R. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
Absolute bioavailability
animal experiment
animal tissue
area under the curve
Article
chromatography
controlled study
cystine
Cystine
Distribution
drug bioavailability
drug determination
drug half life
female
intestine tissue
LC-MS/MS
limit of quantitation
liquid chromatography-mass spectrometry
male
mass spectrometry
matrix effect
maximum concentration
mouse
multiple reaction monitoring
nonhuman
Pharmacokinetics
quantitative analysis
reproducibility
sensitivity and specificity
time to maximum plasma concentration
tissue distribution
tissue homogenate
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