Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

Development of a novel in vivo lung perfusion (IVLP) procedure allows localized delivery of high-dose doxorubicin (DOX) for targeting residual micrometastatic disease in the lungs. However, DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent...

Full description

Bibliographic Details
Main Authors: Bojko, B. (Author), Cypel, M. (Author), Gómez-Ríos, G. (Author), Goryński, K. (Author), Keshavjee, S. (Author), Kupcewicz, B. (Author), Looby, N. (Author), Olkowicz, M. (Author), Pawliszyn, J. (Author), Ramadan, K. (Author), Reck dos Santos, P. (Author), Roszkowska, A. (Author), Tascon, M. (Author), Waddell, T.K (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
adriamycinone
adult
aged
animal experiment
animal model
animal tissue
Article
cardiolipin
clinical article
computer assisted tomography
controlled study
creatine
cross validation
doxorubicin
doxorubicinol
doxorubicinolone
drug metabolite
drug monitoring
drug therapeutic index
female
follow up
forced expiratory volume
forced vital capacity
high performance liquid chromatography
human
human tissue
In vivo solid phase microextraction
in vivo study
liquid chromatography-mass spectrometry
lung metastasis
lung parenchyma
lung perfusion
male
metabolic fingerprinting
Metabolite profiling
metabolomics
metastasis resection
mouse
nitinol
nonhuman
operation duration
osteosarcoma
phosphate
phosphate blood level
polyacrylonitrile
rat
segmentectomy
solid phase microextraction
Spatial resolution
tandem mass spectrometry
Therapeutic drug monitoring
Tissue analysis
tumor volume
unclassified drug
wedge resection
young adult
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items