UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine

UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine

Cyclic 3′,5′-adenosine monophosphate (cAMP) and cyclic 3′,5′-guanosine monophosphate (cGMP) are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese medicine. However, phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in t...

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Bibliographic Details
Main Authors: Di, X. (Author), Du, Y. (Author), Liu, Y. (Author), Wang, X. (Author), Wu, C. (Author), Xu, M. (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
ammonium acetate
animal experiment
animal model
Article
biological marker
cAMP
cGMP
Chinese medicine
controlled study
cyclic AMP
cyclic GMP
electrospray
enzyme stability
ex vivo study
glucose
glucose blood level
limit of quantitation
male
mass spectrometry
methanol
multiple reaction monitoring
non insulin dependent diabetes mellitus
nonhuman
perchloric acid
Plasma
rat
rat model
Rehmannia glutinosa
Rehmannia glutinosa extract
theophylline
UHPLC-MS/MS
ultra performance liquid chromatography
yin deficiency
yin-yang
Yin-Yang disharmony
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