Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota. This study focused on the CYP51 enzyme of intestinal bact...

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Bibliographic Details
Main Authors: Cong, L. (Author), Fu, J. (Author), Han, P. (Author), Jiang, J.-D (Author), Ma, S.-R (Author), Pan, L.-B (Author), Peng, R. (Author), Wang, Y. (Author), Yu, H. (Author), Zhang, Z.-W (Author)
Format: Article
Language:English
Published: Xi'an Jiaotong University 2021
Subjects:
Acinetobacter baumannii
animal experiment
area under the curve
Article
bacterial strain
bacterium culture
berberine
Berberine
beroline
Bifidobacterium longum
Biotransformation
comparative study
controlled study
crystal structure
CYP51
Demethylated metabolite
demethylation
drug half life
drug metabolism
drug metabolite
drug transformation
Enterococcus faecalis
Enterococcus faecium
Escherichia coli
feces
Gut microbiota
human
in vitro study
in vivo study
Institute for Cancer Research mouse
intestine absorption
intestine flora
kidney
kidney homogenate
Klebsiella pneumoniae
limit of quantitation
liver
liver homogenate
male
mean residence time
molecular docking
mouse
nonhuman
plasma concentration-time curve
Proteus mirabilis
Pseudomonas aeruginosa
RNA 16S
Staphylococcus aureus
Staphylococcus epidermidis
sterol 14alpha demethylase
thalifendine
voriconazole
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