Self-assembled Camptothecin derivatives – Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy

Camptothecin (CPT), an alkaloid, was first discovered from plants and has potent anti-tumor activity. Since then, CPT analogs (namely Irinotecan and Topotecan) have been approved by the FDA for cancer treatments. Curcumin, on the other hand, is a widely used photosensitizer in photodynamic therapy (...

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Bibliographic Details
Main Authors:	Chin, W.-C (Author), Guo, L. (Author), Guo, Y. (Author), Li, C. (Author), Liu, H. (Author), Liu, J. (Author), Liu, Y. (Author), Sedlařík, V. (Author), Xiao, H. (Author), Yuan, M. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	animal experiment animal model animal tissue antineoplastic activity antineoplastic agent Antineoplastic Agents Anti-tumor efficacy apoptosis Apoptosis Article camptothecin Camptothecin cancer combination chemotherapy cell viability chemistry Combination therapy Combined Modality Therapy confocal microscopy controlled study curcumin curcuminoid derivative Diarylheptanoids dichlorodihydrofluorescein diacetate drug conjugation drug delivery system Drug delivery system drug effect drug efficacy drug uptake heptane derivative HT-29 cell line HT29 Cells human Humans in vivo study intracellular space Intracellular Space irinotecan male metabolism mouse multimodality cancer therapy nanoparticle nonhuman photochemotherapy Photochemotherapy photodynamic therapy Photodynamic therapy priority journal procedures radiation response singlet oxygen topotecan unclassified drug
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Self-assembled Camptothecin derivatives – Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy

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