Attritional evaluation of lipophilic and hydrophilic metallated phthalocyanines for oncological photodynamic therapy

Attritional evaluation of lipophilic and hydrophilic metallated phthalocyanines for oncological photodynamic therapy

Background and aim: Oncological photodynamic therapy (PDT) relies on photosensitizers (PSs) to photo-oxidatively destroy tumor cells. Currently approved PSs yield satisfactory results in superficial and easy-to-access tumors but are less suited for solid cancers in internal organs such as the biliar...

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Main Authors: Cavaco, J.E.B (Author), de Haan, L.R (Author), de Keijzer, M.J (Author), de Klerk, D.J (Author), Desclos, E. (Author), Dias, L.M (Author), Ding, B. (Author), Ernst, D. (Author), Franchi, L.P (Author), Heger, M. (Author), Huang, X. (Author), Kochan, J.A (Author), Krawczyk, P.M (Author), Mesquita, B. (Author), Pan, W. (Author), Photodynamic Therapy Study Group (Author), Scutigliani, E.M (Author), Sharifi, F. (Author), Tedesco, A.C (Author), van Wijk, A.C (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
A-431 cell line
Aluminum phthalocyanine
antineoplastic agent
Antineoplastic Agents
apoptosis
Apoptosis
Article
cancer therapy
cell death
Cell Line, Tumor
cell membrane permeability
Cell Membrane Permeability
cell proliferation assay
Cell survival
cell viability assay
chemistry
comparative study
confocal microscopy
Dark toxicity
Dose-Response Relationship, Radiation
drug carrier
Drug Carriers
Drug Liberation
drug release
epidermal growth factor receptor
flow cytometry
fluorescence analysis
G2 phase cell cycle checkpoint
human
human cell
Humans
incubation time
indole derivative
Indoles
LC50
liposome
Liposomes
oncological photodynamic therapy
percentage of cells in G0/G1 phase
photochemotherapy
Photochemotherapy
photodynamic therapy
photosensitization
Photosensitizers, cell death
photosensitizing agent
Photosensitizing Agents
Phototoxicity
phthalocyanine
phthalocyanine aluminum
phthalocyanine zinc
protein expression
radiation response
S phase cell cycle checkpoint
signal transduction
structure activity relation
Structure-Activity Relationship
time factor
Time Factors
treatment response
tumor cell line
tumor suppressor gene
Zinc phthalocyanine
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