On the waiting time until coordinated mutations get fixed in regulatory sequences

On the waiting time until coordinated mutations get fixed in regulatory sequences

In this paper we consider the time evolution of a population of size N with overlapping generations, in the vicinity of m genes. We assume that this population is subject to point mutations, genetic drift, and selection. More specifically, we analyze the statistical distribution of the waiting time...

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Bibliographic Details
Main Authors: Bechly, G. (Author), Gauger, A. (Author), Hössjer, O. (Author)
Format: Article
Language:English
Published: Academic Press 2021
Subjects:
Article
binding site
Binding site
Binding Sites
biological model
Continuous time Markov process
Coordinated mutations
DNA sequencing
Evolution, Molecular
gene expression
genetic drift
Genetic Drift
genetic selection
genetics
hospital admission
human
Humans
Markov chain
mathematical computing
Models, Genetic
molecular evolution
Moran model
mutation
Mutation
mutational analysis
numerical model
Phase-type distribution
point mutation
population dynamics
population genetics
promoter region
regulatory sequence
Regulatory sequence
selection
Selection, Genetic
statistical distribution
transcription factor
Transcription Factors
Waiting Lists
Waiting time
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