Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome after Hematopoietic Cell Transplantation

Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations Are Associated with the Stool Bacterial Microbiome after Hematopoietic Cell Transplantation

Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplantation (HCT). MMF has a narrow therapeutic index, and blood concentrations of mycophenolic acid (MPA), the active component of MMF, are highly variable. Low MPA concentrations are associat...

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Bibliographic Details
Main Authors: Al-Kofahi, M. (Author), Carlson, B. (Author), Holtan, S. (Author), Jacobson, P.A (Author), Jurdi, N.E (Author), Kaiser, T. (Author), Khoruts, A. (Author), MacMillan, M. (Author), Rashidi, A. (Author), Saqr, A. (Author), Staley, C. (Author), Weisdorf, D. (Author), Young, J.-A (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Beta glucuronidase
Enterohepatic recycling
Microbiome
Mycophenolate mofetil
Mycophenolic acid
Pharmacokinetics
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