Combining mutation and horizontal gene transfer in a within-host model of antibiotic resistance

Combining mutation and horizontal gene transfer in a within-host model of antibiotic resistance

Antibiotics are used extensively to control infections in humans and animals, usually by injection or a course of oral tablets. There are several methods by which bacteria can develop antimicrobial resistance (AMR), including mutation during DNA replication and plasmid mediated horizontal gene trans...

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Bibliographic Details
Main Authors: Benschop, J. (Author), Burgess, S. (Author), French, N.P (Author), Marshall, J.C (Author), Roberts, M.G (Author), Toombs-Ruane, L.J (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2021
Subjects:
animal
Animals
Anti-Bacterial Agents
Antibiotic controls
antibiotic resistance
Antibiotic resistance
Antibiotics
antiinfective agent
Antimicrobial resistance
Antimicrobial resistances
Article
Bacteria
Bacteria (microorganisms)
bacterial growth
bacterial load
bacterial mutation
bacterial strain
bacterium
bacterium conjugation
Bifurcation diagram
biological model
Cell proliferation
coliform bacterium
controlled study
DNA
DNA replication
drug effect
Drug Resistance, Bacterial
Dynamical systems
Escherichia coli
gene transfer
Gene transfer
Gene Transfer, Horizontal
Genes
genetics
horizontal gene transfer
Horizontal gene transfer
Host Microbial Interactions
human
Humans
infection control
infection prevention
mathematical computing
mobile genetic element
Models, Biological
mutation
Mutation
nonhuman
plasmid
Plasmid dynamics
Plasmids
Prevention and controls
quinolone derivative
Reproduction numbers
Selection pressures
steady state
wild type
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