Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation
Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to inves...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier GmbH
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |