Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy

Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy

Pulp injury is one of the most common clinical diseases, and severe cases are usually associated with the functional loss of the tooth, while the current clinical treatment modality is only a cavity filling procedure without the regeneration of the dentin-pulp complex, thus leading to a devitalized...

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Bibliographic Details
Main Authors: Bu, W. (Author), Jin, N. (Author), Li, X. (Author), Liu, L. (Author), Meng, Y. (Author), Sun, H. (Author), Wang, D. (Author), Wang, Y. (Author), Xu, X. (Author), Zhou, D. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Activation analysis
Ascorbic acid
Autophagy
Biocompatibility
Blood vessels
Carbon dots
Cell adhesion
Cell death
Chemical activation
Clinical disease
Dental pulp stem cells
Dentine-pulp complex regeneration
Dentin-pulp complex regeneration
Electrophoresis
Extracellular matrices
Extracellular matrix
Molecular dynamics
mTOR signaling
PI3K/Akt
PI3K/akt/mTOR signaling pathway
PI3K/Akt/mTOR signaling pathway
Signalling pathways
Stem cells
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