Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

Full description

Bibliographic Details
Main Authors: Arab, T. (Author), Borjabad, A. (Author), Haughey, N.J (Author), Hollinger, K.R (Author), Huang, Y. (Author), Kim, B.-H (Author), Lovell, L. (Author), Moniruzzaman, M. (Author), Slusher, B.S (Author), Thomas, A.G (Author), Turchinovich, A. (Author), Volsky, D.J (Author), Witwer, K.W (Author), Zhu, X. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2022
Subjects:
Depression
EcoHIV
Extracellular vesicle
HIV
Mice
Neutral sphingomyelinase 2
Sleep
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items