PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules. Combinations of chemotherapy and PEGPH20, however, have been unsuccessful in Phase III clinical trials. We hypothe...

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Bibliographic Details
Main Authors: Brender, J.R (Author), Chandramouli, G.V (Author), Devasahayam, N. (Author), Kishimoto, S. (Author), Krishna, M.C (Author), Lee, J. (Author), Mitchell, J.B (Author), Otowa, Y. (Author), Saida, Y. (Author), Seki, T. (Author), Yamamoto, K. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
Hypoxia
Pancreatic Cancer
PEGPH20
Preclinical
Radiation Resistance
Tumor Microenvironment
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