Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer

Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and incidence rates are continuing to rise globally. Patients often present with locally advanced disease and a staggering 50% chance of relapse following treatment. Aberrant activation of adaptive response signali...

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Bibliographic Details
Main Authors: Amelio, A.L (Author), Carper, M.B (Author), Cohen, S. (Author), Damrauer, J.S (Author), Gentile, G.M (Author), Goel, S. (Author), Kimple, R.J (Author), Murphy, R.M (Author), Nickel, K.P (Author), Parag-Sharma, K. (Author), Sato, K. (Author), Yarbrough, W.G (Author), Zhang, A.M (Author), Zimmerman, M.P (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
cAMP Regulated transcription coactivators
CREB
Head and neck cancer
HPV(+) oropharyngeal cancer
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