Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure

Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure

Earlier initiation of smoking correlates with higher risk of nicotine dependence, mental health problems, and cognitive impairments. Additionally, exposure to nicotine and/or tobacco smoke during critical developmental periods is associated with lasting epigenetic modifications and altered gene expr...

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Bibliographic Details
Main Authors: Gitik, M. (Author), Goldman, D. (Author), Gould, T.J (Author), Holliday, E.D (Author), Leung, M. (Author), Logue, S.F (Author), Tikkanen, R. (Author), Yuan, Q. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2018
Subjects:
Addiction
Adolescence
adult
age
Age Factors
animal
animal experiment
Animals
Article
Bahcc1 gene
C57BL mouse
choline
Choline
chromatin assembly and disassembly
Chromatin Assembly and Disassembly
cigarette smoking
Cigarette Smoking
conditioned reflex
Conditioning, Classical
Development
diet supplementation
DNA methylation
DNA Methylation
DNA modification
dorsal hippocampus
drug effect
environmental exposure
Epigenesis, Genetic
Epigenetics
fear
Fear
gene
gene expression
genetic epigenesis
genetics
hippocampus
Hippocampus
Learning
learning disorder
male
Male
metabolism
Mice, Inbred C57BL
mouse
nicotine
Nicotine
nonhuman
perinatal period
physiology
psychology
Smarca2 gene
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Internet

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