Disruption of dorsal hippocampal – prefrontal interactions using chemogenetic inactivation impairs spatial learning

Disruption of dorsal hippocampal – prefrontal interactions using chemogenetic inactivation impairs spatial learning

The hippocampus (HPC) and prefrontal cortex (PFC) are both necessary for learning and memory-guided behavior. Multiple direct and indirect anatomical projections connect the two regions, and HPC – PFC functional interactions are mediated by diverse physiological network patterns, thought to sub serv...

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Bibliographic Details
Main Authors: Dai, Y.Y (Author), Glantz, E.H (Author), Jadhav, S.P (Author), Maharjan, D.M (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2018
Subjects:
adult
animal
animal behavior
animal experiment
animal tissue
Animals
Article
brain chemogenetic inactivation
connectome
controlled study
designer receptors exclusively activated by designer drug
dorsal hippocampus
Dorsal hippocampus
DREADDs
hippocampus
Hippocampus
learning disorder
Long Evans rat
mental task
nerve tract
Neural Pathways
neurological and sensorial procedures
nonhuman
physiology
prefrontal cortex
Prefrontal cortex
Prefrontal Cortex
rat
Rats, Long-Evans
receptor
Spatial alternation task
spatial behavior
spatial learning
Spatial learning
Spatial Learning
spatial memory
Spatial Memory
spatial orientation
Spatial working memory
unclassified drug
working memory
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