Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm

Discrimination of similar spatial locations, an important feature of episodic memory, has traditionally been measured via delayed nonmatching-to-location tasks. Recently, we and others have demonstrated that touchscreen-based Trial Unique Nonmatching-to-Location (TUNL) tasks are sensitive to lesions...

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Bibliographic Details
Main Authors:	Brigman, J.L (Author), Castillo, R. (Author), Holmes, A. (Author), Kenton, J.A (Author)
Format:	Article
Language:	English
Published:	Academic Press Inc. 2018
Subjects:	129 mouse animal animal behavior animal experiment Animals Article Behavior, Animal brain cortex C57BL mouse CA1 Region, Hippocampal Cerebral Cortex cohort analysis controlled study depth perception discrimination learning Discrimination Learning episodic memory genetics hippocampal CA1 region hippocampus instrumental conditioning learning metabolism Mice, 129 Strain Mice, Inbred C57BL Mice, Transgenic mouse mouse mutant n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor GluN2B subunit nerve cell plasticity nonhuman NR2B NMDA receptor operant behavioral test physiology Practice (Psychology) protein depletion psychomotor performance Psychomotor Performance Receptors, N-Methyl-D-Aspartate spatial learning Spatial Learning task performance touchscreen transgenic mouse trial unique nonmatching to location task unclassified drug vision Visual Perception
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Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm

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