Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression

Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression

We developed a novel lentiviral vector, pseudotyped with the F and HN proteins from Sendai virus (rSIV.F/HN), that produces long-lasting, high-efficiency transduction of the respiratory epithelium. Here we addressed whether this platform technology can secrete sufficient levels of a therapeutic prot...

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Bibliographic Details
Main Authors: Alton, E.W.F.W (Author), Ashek, A. (Author), Atsumi, N. (Author), Aziz, K. (Author), Bhargava, A. (Author), Clarke, N. (Author), Gill, D.R (Author), Griesenbach, U. (Author), Hyde, S.C (Author), Juarez-Molina, C.I (Author), Lund-Palau, H. (Author), Meng, C. (Author), Morgan, C. (Author), Padley, S. (Author), Pilou, A. (Author), Takata, M. (Author), Wilson, M.R (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
alveolar macrophage
autoimmune pulmonary alveolar proteinosis
gene therapy
GM-CSF
granulocyte-macrophage colony-stimulating factor
lentiviral vector
lung gene therapy
PAP
rSIV.F/HN
surfactant protein
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