AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia, cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of the maternal copy of the paternally imprinted UBE3A gene, with current precision therapy approaches focusing on re-expression o...

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Bibliographic Details
Main Authors: Augusto, J. (Author), Campbell, A. (Author), Conroy, R.M (Author), Henshall, D.C (Author), Jensen, M.A (Author), Kesavan, J.C (Author), Kielpinski, L. (Author), Kremer, T. (Author), Langa, E. (Author), Miller, M.T (Author), Morris, G. (Author), Nguyen, N.T (Author), Reschke, C.R (Author), Sanfeliu, A. (Author), Worm, J. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
Angelman syndrome
Behavior
Cerebellum
epilepsy
Hippocampus
microRNAs
miR-134
MT: Oligonucleotides: Therapies and Applications
seizures
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