HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing

HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing

Recent advances in CRISPR-Cas9 techniques, especially the discovery of base and prime editing, have significantly improved our ability to make precise changes in the genome. We hypothesized that modulating certain endogenous pathway cells could improve the action of those editing tools in mammalian...

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Bibliographic Details
Main Authors: Hu, Y. (Author), Jiao, Y. (Author), Lin, G. (Author), Liu, J. (Author), Liu, N. (Author), Wang, Y. (Author), Yang, S. (Author), Yao, S. (Author), Zhou, L. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
base editing
CRISPR-Cas9
HDAC inhibitors
MT: RNA/DNA Editing
prime editing
product purity
UNG
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