DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D

DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D

Although chimeric antigen receptor T (CAR-T) cells have achieved remarkable successes in hematological malignancies, the efficacies of CAR-T cells against solid tumors remains unsatisfactory. Heterogeneous antigen expression is one of the obstacles on its effective elimination of solid cancer cells....

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Bibliographic Details
Main Authors: Cui, Y. (Author), Hu, D. (Author), Jiang, Z. (Author), Li, M. (Author), Li, P. (Author), Li, S. (Author), Li, Y. (Author), Liu, P. (Author), Liu, S. (Author), Long, Y. (Author), Qin, L. (Author), Shi, J. (Author), Tang, Q. (Author), Tang, Z. (Author), Wang, S. (Author), Wang, X. (Author), Wu, Q. (Author), Yang, L.-H (Author), Yao, Y. (Author), Zhang, Z. (Author), Zhao, R. (Author), Zheng, D. (Author), Zhong, M. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
CAR-T cells
DAP10
glypican 3
immunotherapy
NKG2D
tumor heterogeneity
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