Loss of heterozygosity of MIR15A/MIR16-1, negative regulators of the antiapoptotic gene BCL2, is not common in odontogenic keratocysts

Loss of heterozygosity of MIR15A/MIR16-1, negative regulators of the antiapoptotic gene BCL2, is not common in odontogenic keratocysts

Objectives: The odontogenic keratocyst (OKC) is an aggressive odontogenic cyst that has a high recurrence rate. Apart from PTCH1 mutations, few molecular alterations are described in OKCs. Low expression of microRNAs (miRNAs) miR-15a and/or miR-16-1 in association with increased expression of their...

Full description

Bibliographic Details
Main Authors: Asevedo Campos de Resende, T. (Author), Carolina da Silva, J. (Author), Cavalieri Gomes, C. (Author), de Fátima Bernardes, V. (Author), De Marco, L.A (Author), Gonçalves Diniz, M. (Author), Santiago Gomez, R. (Author)
Format: Article
Language:English
Published: Mosby Inc. 2018
Subjects:
adolescent
Adolescent
adult
Adult
capillary electrophoresis
chromosome 13
Chromosomes, Human, Pair 13
DNA fragmentation
DNA Fragmentation
Electrophoresis, Capillary
female
Female
genetics
heterozygosity loss
human
Humans
Loss of Heterozygosity
male
Male
microRNA
MicroRNAs
middle aged
Middle Aged
MIRN15 microRNA, human
MIRN16 microRNA, human
odontogenic cyst
Odontogenic Cysts
odontogenic tumor
Odontogenic Tumors
pathology
polymerase chain reaction
Polymerase Chain Reaction
protein bcl 2
Proto-Oncogene Proteins c-bcl-2
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items