Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase

Objectives: Tumour-positive resection margins are a major problem during oral cancer surgery. gGlu-HMRG is a tracer that becomes fluorescent upon activation by gamma-glutamyltranspeptidase (GGT). This study aims to investigate the combination of gGlu-HMRG and a clinical fluorescence imaging system f...

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Bibliographic Details
Main Authors: Bhairosingh, S.S (Author), Boonstra, M.C (Author), Chan, A. (Author), de Haan, L.M (Author), Handgraaf, H.J.M (Author), Keereweer, S. (Author), Kobayashi, H. (Author), Löwik, C.W.G.M (Author), Que, I. (Author), Slooter, M.D (Author), Vahrmeijer, A.L (Author), van der Velden, L.-A (Author), van Driel, P.B.A.A (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
animal
animal experiment
animal model
Animals
Article
Bagg albino mouse
cancer cell
cancer surgery
Carcinoma, Squamous Cell
controlled study
ex vivo study
FaDu cell line
female
Female
Fluorescence
fluorescence imaging
fluorescent dye
Fluorescent Dyes
gamma glutamyltransferase
gamma-Glutamyltransferase
Head and neck neoplasms
Heterografts
histopathology
human
human cell
human tissue
Humans
in vitro study
Margins of excision
Margins of Excision
metabolism
Mice
Mice, Inbred BALB C
Mice, Nude
mouse
mouth cancer
Mouth Neoplasms
mouth tumor
nonhuman
nude mouse
Optical imaging
Oral cavity
priority journal
protein expression
rat
sensitivity and specificity
squamous cell carcinoma
Squamous cell carcinoma
stroma cell
surgical margin
xenograft
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