STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer

STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer

Objectives: The intracellular DNA sensor stimulator of interferon genes (STING) has recently been shown to play a vital role in anti-viral and anti-tumor immune responses stimulating cytokine production. While human papillomavirus (HPV) is a causative agent for a subset of head and neck squamous cel...

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Bibliographic Details
Main Authors: Concha-Benavente, F. (Author), Ferris, R.L (Author), Gibson, S.P (Author), Gooding, W.E (Author), Lu, S. (Author), Shayan, G. (Author), Srivastava, R.M (Author), Wang, L. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adaptor protein
Alphapapillomavirus
Antineoplastic Agents, Immunological
Article
cancer prognosis
cancer specific survival
CD83 antigen
CD86 antigen
cell activation
Cell Line, Tumor
cell maturation
cetuximab
Cetuximab
clinical feature
clinical outcome
controlled study
dendritic cell
Dendritic cells
down regulation
drug effect
gene activation
gene expression
Head and Neck Neoplasms
head and neck squamous cell carcinoma
head and neck tumor
HLA DR antigen
HNSCC
HPV
human
human cell
human tissue
Humans
immunohistochemistry
immunological antineoplastic agent
immunology
in vitro study
isolation and purification
Killer Cells, Natural
lymph node metastasis
membrane protein
Membrane Proteins
messenger RNA
metabolism
natural killer cell
Natural killer cells
papillomavirus infection
priority journal
programmed death 1 ligand 1
protein expression
Squamous Cell Carcinoma of Head and Neck
STING
STING protein
Tmem173 protein, human
tumor cell line
tumor volume
unclassified drug
upregulation
virology
Western blotting
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